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چکیده
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Introduction: Acromegaly is often associated with alterations in carbohydrate metabolism, ranging from impaired glucose tolerance to overt diabetes mellitus (DM). This study aimed to evaluate the serum concentrations of TNF -α and IL -10, along with other biochemical parameters, in patients with acromegaly and concomitant diabetes. Furthermore, we sought to investigate the associations between these parameters. Additionally, this study investigated the prevalence of Cytomegalovirus (CMV) infection and its potential correlation with TNF -α, IL -10, and other biochemical parameters in this patient population. Methods: Serum concentrations of TNF -α and IL -10 were measured in 50 patients with acromegaly and concomitant diabetes and 50 healthy controls using commercially available ELISA kits. CMV DNA was detected in serum samples using a qualitative PCR assay targeting the CMV late antigen gp64 gene. Results: Patients with acromegaly and concomitant diabetes exhibited significantly higher levels of IGF -1, insulin, HOMA -IR, cholesterol, triglycerides, LDL, VLDL, ALT, AST, bone -specific alkaline phosphatase (BALP), TNF -α, and IL -10 compared to the control group (all P<0.05). CMV infection was detected in 1.9% (1/50) of the healthy control group and 23.5% (12/50) of the acromegaly and diabetes group. Within the acromegaly and diabetes group, CMV -positive patients had significantly higher levels of TNF -α and IL -10 compared to CMV -negative patients (both P<0.05). Conclusion: This study demonstrated a significant association between elevated levels of TNF -α and IL -10 and acromegaly with concomitant diabetes. Further research is needed to determine if these cytokines play a causal role in the pathogenesis of these comorbidities. The observed increase in ALT, AST, and BALP levels in patients suggests potential liver and bone involvement in acromegaly with concomitant diabetes. Moreover, a higher prevalence of CMV infection was observed in patients with acromegaly and concomitant diabetes compared to healthy controls, suggesting a potential link between CMV infection and this patient population. Further research is warranted to elucidate the nature of this association and its potential clinical implications .
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