مشخصات پژوهش

عنوان	An in-vitro study on a novel six-phage cocktail against multi-drug resistant-ESBL Shigella in aquatic environment
نوع پژوهش	مقاله چاپ‌شده
کلیدواژه‌ها	bacteriophage, bio-control, in-vitro, phage, phage cocktail, Shigella, water-borne
چکیده	Abstract Shigella spp. are water-borne pathogens responsible for mild to severe cases bacilli dysentery all around the world known as Shigellosis. The progressively increasing of antibiotic resistance among Shigella calls for developing and establishing novel alternative therapeutic methods. The present study aimed to evaluate a novel phage cocktail of lytic phages against extended spectrum beta lactamase isolates of Shigella species in an aquatic environment. The phage cocktail containing six novel Shigella specific phages showed a broad host spectrum. The cocktail was very stable in aquatic environment. The cocktail resulted in about 99% decrease in the bacterial counts in the contaminated water by several species and strains of Shigella such as Shigella sonnei, Shigella flexneri and Shigella dysenteriae. Achieving such a high efficiency in this in-vitro study demonstrates a high potential for in-vivo and in-situ application of this phage cocktail as a bio-controlling agent against Shigella spp. contamination and infections.
پژوهشگران	ران ونگ (نفر ششم به بعد)، مجید بوذری (نفر ششم به بعد)، مجتبی منصوریان فر (نفر ششم به بعد)، محدثه برازنده (نفر ششم به بعد)، تاو ها (نفر ششم به بعد)، مجید کمیجانی (نفر ششم به بعد)، عباس سلیمانی دلفان (نفر پنجم)، ابوالقاسم هدایتخواه (نفر چهارم)، هونگ دو باو (نفر سوم)، لیلی زانگ (نفر دوم)، خشایار شاهین (نفر اول)