مشخصات پژوهش

عنوان	IN VITRO RELEASE BEHAVIOR AND EX VIVO EVALUATION OF QUERCETIN-MICROEMULSIONS FOR TOPICAL DELIVERY
نوع پژوهش	مقاله ارائه‌شده
کلیدواژه‌ها	Microemulsion, drug delivery, Quercetin
چکیده	This work was aimed for developing release behaviour, release kinetics and mechanisms as well as evaluation of ex vivo drug penetration for delivery of the anti-oxidant drug named quercetin encapsulated in microemulsion formulations composed of Tween 80 as surfactant, Transcutol® P as co-surfactant, oleic acid as oil phase and water as aqueous phase. The obtained results showed a slow release behavior without any transdermal delivery. Most of the formulations fitted best with zero-order kinetics and had non-Fickian dissolution mechanisms that could be worthwhile for topical administrations. This study illustrated that the proposed QU-microemulsion formulation has a good potential for use in sunscreen formulations.
پژوهشگران	علیرضا صلابت (نفر دوم)، آذر کجباف والا (نفر اول)