عنوان	Injectable pH-responsive cross-linked chitosan hydrogel co-delivering methotrexate and diaminoperylene bisimide: Enhanced targeted chemo-photodynamic therapy for breast cancer cells with reduced systemic toxicity
نوع پژوهش	مقاله چاپ‌شده
کلیدواژه‌ها	pH-sensitive hydrogel Chitosan Methotrexate (MTX) Diaminoperylene bisimide (DA-PBI) Chemo-photodynamic therapy Breast cancer pH-responsive drug release
چکیده	Breast cancer therapy continues to face major challenges due to drug resistance and the severe side effects of conventional chemotherapy. To address these issues, an injectable and pH-responsive chitosan hydrogel was designed for the co-delivery of methotrexate (MTX) and diaminoperylene bisimide (DA-PBI), enabling a synergistic combination of chemotherapy and photodynamic therapy. The hydrogel matrix, cross-linked with glutaraldehyde, successfully maintained DA-PBI in its monomeric state, enabling efficient singlet oxygen generation
پژوهشگران	علیرضا کریمی (نفر سوم)، فرناز آزادیخواه (نفر اول)، مهسا طریقت جو (نفر پنجم)، مهناز هادی زاده (نفر چهارم)، فرنوش آزادیخواه (نفر دوم)