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چکیده
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The efficacy of pharmaceutical agents and minimizing their adverse effects on the body are major concerns in biomedical research. One promising strategy to address these challenges is to enhance the targeted delivery of drugs to target sites. This study investigates the feasibility of synthesizing a biodegradable composite of milk proteins for use in drug delivery systems. After synthesis, the structural features of the composite were characterized using a wide range of advanced techniques, including field emission scanning electron microscopy (FE-SEM), Vibrational Magneto-Metric (VSM), and Brunauer-Emmett-Teller (BET) surface analysis. The adsorption capacity of the composite for anthocyanoside drug adsorption and its controlled release was then evaluated. For this purpose, key operational parameters—including pH, initial drug concentration, adsorbent dose, temperature, and contact time—were optimized. The most important characteristics of the prepared composite are its high porosity and magnetic property of 18 emu/g. At pH 5, drug concentration of 20 mg/L, adsorbent amount of 0.5 g/L, temperature of 25°C, and contact time of 15 min, an adsorption efficiency of 92.0±0.4% was observed. The results of composite degradation and drug release showed that the highest weight loss of the composite (75%) occurred under alkaline conditions, while drug release occurred at a near-neutral pH of 7 and physiological temperature of 25°C.
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