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چکیده
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Background: Infertility is a significant issue for young men of reproductive age who are undergoing chemotherapy. Typically, chemotherapy drugs affect rapidly dividing germ cells, resulting in compromised spermatogenesis and a decrease in sperm count among cancer survivors. Objective: This study investigated the effects of taxol on sperm parameters and oxidative stress and antioxidant properties of zinc oxide nanoparticles in adult male NMRI mice. Materials and Methods: For doing this research at Arak University, Arak, Iran in 2023, 24 adult male NMRI mice (35 ± 2 gr, 8 wk) were divided into 4 groups (n = 6/each), control, taxol (5 mg/kg), zinc oxide nanoparticles (5 mg/kg) and taxol+zinc oxide nanoparticles groups. Animals were intraperitoneally treated for 35 days. Then, mice were anesthetized, and the caudal region of the left epididymis was used to measure the sperm parameters and the right testis to calculate the daily sperm production. Total antioxidant capacity and malondialdehyde levels were also measured and compared between groups. Results: Infertility is a significant issue for young men of reproductive age who are undergoing chemotherapy. Typically, chemotherapy drugs affect rapidly dividing germ cells, resulting in compromised spermatogenesis and a decrease in sperm count among cancer survivors. Conclusion: The results of this research indicated that zinc oxide nanoparticles, because of their strong and effective antioxidant characteristics, have the ability to mitigate the harmful impacts of taxol on sperm quality.
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