Background. The Asparagus officinalis L. (AO) is a vegetable (dish plant) consumed in most part of the world especially Arabic countries like Iraq. Asparagus possesses main bioactive phytochemicals including flavonoids, steroidal saponins, dietary fiber and oligosaccharides that involving in its antioxidative, anti-inflammatory, antitumor, hypolipidemic, and antifungal activities. Chemically the plant contains saponins including asparagosides the acrimonious steroid saponins, fructans amino acids, ferulic acid, minerals, vitamins, and flavonoids reported. Based on traditional medicine and anecdotal data, AO exerts anticancer, antimicrobial, antioxidative, hypolipidemic, antidiabetic effects. Monosodium glutamate (MSG), also known as sodium glutamate, is the sodium salt of glutamic acid a white crystalline powder substance, the sodium salt of glutamic acid, that has little flavour itself but enhances the flavour of proteins either by increasing the amount of saliva produced in the mouth or by stimulating the taste buds: used as a food additive, esp in Chinese foods Glutamic acid comes from compounds called glutamates, which are responsible for the "umami". Materials and methods: biochemical and histological parameters the first group, G1: the negative control group, which is the group treated with normal saline physiological solution only orally at a rate of 2 ml / liter, which is equal to what was dosed from a monosodium glutamate (MSG) solution daily for a month. The second group: the positive control group G2 developed hepatotoxicity, by dosing it orally with monosodium glutamate MSG at a concentration of 15 mg /kg of body weight (where 15 mg of the substance is dissolved per kg of body weight in 2 milliliters of distilled water) daily for a month. It is a positive control group based on the half-lethal dose, which is 15 gm per kg, according to the conclusion. The third group G3: the group that was dosed orally with aqueous extract of Asparagus at a concentration of 400 mg / kg per day for a month. The fourth group G4: the group that was dosed with monosodium glutamate at a concentration 15 mg / kg of body weight after 4 hours of treatment with aqueous extract of asparagus orally at a concentration of 400 mg / kg per day for a month, The fifth group, G5: which was dosed orally with an aqueous extract of asparagus at a concentration of 600 mg / kg per day for a month, The Sixth group G6: the group that was dosed with monosodium glutamate at a concentration of 15 mg / kg of body weight after 4 hours of treatment with aqueous extract of asparagus orally at a concentration of 600 mg / kg per day for a month Oral dosing of rabbits treated with MSG and aqueous extract of asparagus. Resulted: The results of the study showed that at a concentration of 400 mg / kg of the aqueous extract group of asparagus plants, there were no significant differences (P > 0.05) to the average levels of HDL and TC, and we also observe a significant decrease (P < 0.05) in the average amount of blood sugar, LDL and TG levels. compared with the control group, as for the extract group Aqueous solution of asparagus plant 400 mg/kg treated by adding MSG in rabbit serum, Also there was significant increase (P < 0.05) in the average level of HDL, and we note a significant decrease (P < 0.05) in the average levels of both LDL,TC,TG, in the blood. The results of the functional study of the concentration at 600 mg / kg of the aqueous extract group of asparagus plants and the aqueous extract group treated with MSG in the serum of white rabbits showed a significant decrease (P < 0.05) in the average level of each of the biochemical parameter’s LDL, TG, TC, and a significant increase (P<0.05 ) in the average level of HDL compared with the control group (positive and negative). The results of the study showed that at a concentration of 15 mg / kg of body weight for the group of MSG in rabbit serum, there was significant decrease (P < 0.05) in the average level of proteins, Albumins, Globulins, and Total protein. The effect of the aqueous extract group of asparagus plant at a concentration of 400 mg / kg and the aqueous extract group treated with MSG on the average level of some proteins in rabbits for a period of one month: in the average level of some proteins, Albumin, Total protein, and a significant decrease (P > 0.05) in the average level of globulin compared with the control group. As for the group of aqueous extract of asparagus 400 mg / kg treated with MSG in rabbit serum, the study indicated that there was a significant decrease (P < 0.05) in the average level of each Proteins Albumin, Globulin, compared to the control group. The effect of the aqueous extract group of asparagus at a concentration of 600 mg / kg and the aqueous extract group treated with MSG on the average level of some proteins in the serum of rabbits for one month, The results of our study of the concentration of 600 mg/kg of the aqueous extract of asparagus in rabbit serum showed that there were no significant differences (P > 0.05) in the average level of some proteins, Albumin, Globulin, and Total protein compared with the control group. As for the aqueous extract of asparagus 600 mg/kg treated with MSG in the serum of rabbits, there was a significant decrease (P < 0.05) in the average level of each of the proteins (Albumin, Globulin, Total protein) compared with the control group. The effect of the aqueous extract group of asparagus at a concentration of 400 mg/kg and the aqueous extract group treated with MSG on the mean level of GSH and MDA in rabbit serum for one month: The results of a study of a concentration of 400 mg/kg of the aqueous extract of asparagus plant with MSG in rabbits showed a significant increase (P < 0.05) in the average GSH level and no differences (P > 0.05) in the MDA level. The results of the functional study showed a concentration of 600 mg / kg for a group of aqueous extract of asparagus plant and a group of aqueous extract of leaves of a plant treated with a substance MSG in rabbits indicates that there is significant increase (P < 0.05) in the average level of GSH and a decrease and the presence of a decrease (P < 0.05) Conclusion: These are experimental studies to evaluate the protective effect of Asparagus officinalis on the liver organ by studying the physiological and the histological effects on liver tissue in male rabbits which induced toxicity (MSG).
