Sage (Salvia officinalis L.) is a valuable medicinal and aromatic plants of the Lamiaceae family. This species is widely used in the pharmaceutical, cosmetics, perfumery, and food industries. Considering the growing need for medicinal plants in the mentioned industries and also the lack of water resources, optimal use of growth inputs is necessary for their production. In this regard, studies have shown that superabsorbent polymer and nutrients play an important role in increasing the yield or active constituents of medicinal plants. In this research, nitrogen (200 kg ha-1), superabsorbent polymer (1500 kg ha-1) and bacteria (Pantoea agglomrans) were used separately and together in a randomized complete block design (RCBD). Parameters such as total phenol, flavonoid, antioxidant capacity and essential oil content were measured and analyzed with statistical analysis software (SAS). The results showed there were no significant differences among treatments for essential oil content. In these cases, it is necessary to analyze other dependent components such as dry weight and essential oil composition and evaluate their results. The amount of total phenol showed a 34% increase compared to the control with the simultaneous use of superabsorbent, nitrogen and biofertilizer. Nitrogen consumption alone decreased the amount of flavonoids, but with the addition of other inputs, this decrease was compensated. The combined use of nitrogen and bacteria (Pantoea agglomrans) increased the antioxidant activity (34%) compared to the control.