1403/03/29
سیدمحمدعلی شریعت زاده (بازنشسته)

سیدمحمدعلی شریعت زاده (بازنشسته)

مرتبه علمی: استاد
ارکید: https://orcid.org/0000-0002-2395-8057
تحصیلات: دکترای تخصصی
اسکاپوس: 15133044400
دانشکده: دانشکده علوم پایه
نشانی: دانشگاه اراک، گروه زیست شناسی
تلفن:

مشخصات پژوهش

عنوان
اثر عصاره چای سبز بر پارامترهای سلامت اسپرم رتهای بالغ تیمار شده با بیسفنول A
نوع پژوهش
مقاله چاپ‌شده
کلیدواژه‌ها
بیسفنول A ، عصاره چای سبز ، پارامترهای سلامت اسپرم
سال 1399
مجله فصلنامه گياهان دارويي
شناسه DOI
پژوهشگران سمانه تقی پور ، سیدمحمدعلی شریعت زاده (بازنشسته) ، ملک سلیمانی مهرنجانی ، آتنا سادات عظیمی

چکیده

Background: Bisphenol A (BPA) disturbs male reproductive system performance via the production of free radicals. Green tea extract (GTE) is known as a potent antioxidant. Objective: The aim of this study was to investigate the effect of cotreatment of BPA and GTE as an antioxidant on male reproductive system performance. Methods: Adult male rats were divided into 4 groups: control, Bisphenol A (20 µg/kg/day), GTE (100 mg/kg/day) and Bisphenol A + GTE, treated for 8 weeks. The body weight and left testis weight were recorded. Left caudal epididymis was separated and kept in Ham's F10. Released sperms were used for analyzing the number, motility, viability and abnormalities of the sperm. The quality of sperm chromatin was assessed by nuclear staining acridine orange and aniline blue. Data were analyzed using one-way ANOVA and Tukey‘s test. The means were considered significant at P < 0.05. Results: A significant reduction in the number, motility and viability of sperm were seen in BPA group compared to the control group (P < 0.001). BPA didn’t have any effect on sperm DNA integrity and histon-protamine replacement (P > 0.05). Also a considerable increase in sperm viability and motility was seen in the GTE group compared to the control. Conclusion: The results of this investigation showed that GTE could compensate the adverse effects of BPA on sperm parameters in adult rats.