A new hybrid antibacterial material was developed by post synthesis grafting method. 3-aminopropyl triethoxysilane (3-APTES) was first anchored over MCM-41 and NaY Zeolite upon reaction with transition metal (M ¼ Mn(II), Co(II) and Cu(II)) complexes of tetradentate Schiff base ligand L: (C22H20N2O2). The prepared materials were characterized by several techniques: chemical analysis, diffuse reflectance spectroscopy (DRS), Fourier transfer infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and BurnereEmmeteTaller(BET). The in vitro antibacterial activity of these compounds was evaluated against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis), as Gram-positive bacteria, and further against Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), as Gram-negative bacteria. Then, the results were compared with standard drugs. The analysis revealed that hybrid materials that prepared by immobilization Schiff base in porous materials show fine inhibition on bacterial growth till 24 h.
