2024 : 4 : 14
Mojgan Zendehdel

Mojgan Zendehdel

Academic rank: Professor
ORCID: https://orcid.org/0000-0003-1890-0317
Education: PhD.
ScopusId: 8613426000
Faculty: Science
Address: Arak University


Synthesis and study the controlled release of etronidazole from the new PEG/NaY and PEG/MCM-41 nanocomposites
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Journal Journal of Environmental Health Science and Engineering
Researchers Mojgan Zendehdel ، Giuseppe Cruciani ، Forozan Kar ، Aboulfazl Barati


Recently, hybrid materials using poly ethylene glycol and porous nanocrystals have been developed for drug release. In this study, a series of poly ethylene glycol (PEG)/NaY zeolite and PEG/MCM-41 nanocomposites get synthesized. These materials are characterized using DFT-IR spectroscopy, XRD, TGA and SEM. After loading the metronidazole onto these nanocomposites, the release of Metronidazole was studied in two kinds of release fluids simulating body fluid KH2PO4-Na2HPO4 buffer (pH = 7.4) and gastric fluid (HCl aqueous solution, pH = 1.5) while controlling the time, pH values, and temperature using UV-vis. Results showed that these nanocomposites have further release related to NaY, MCM-41 and the order of release in two pH solutions was PEG/NaY > PEG/MCM-41 > NaY > MCM-41. The behavior of drug release in these nanocomposites is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.