1403/02/23
محمد پرستش

محمد پرستش

مرتبه علمی: دانشیار
ارکید: https://orcid.org/0000-0002-0273-9955
تحصیلات: دکترای تخصصی
اسکاپوس: 36996681000
دانشکده: دانشکده تربیت بدنی و علوم ورزشی
نشانی: دانشگاه اراک- دانشکده علوم ورزشی- گروه فیزیولوژی و آسیب شناسی ورزشی
تلفن:

مشخصات پژوهش

عنوان
High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin
نوع پژوهش
مقاله چاپ‌شده
کلیدواژه‌ها
Keywords: diabetes mellitus, exercise, endurance training, insulin, streptozotocin
سال 1398
مجله international physiology
شناسه DOI
پژوهشگران جمال امری ، محمد پرستش ، مهدی صادق ، امیر حسین لطیفی ، منا اعلایی

چکیده

Background and aims: In this study, we aimed to investigate the effects of 10 weeks of high-intensity interval training (HIIT) and endurance training (END) on irisin, betatrophin, insulin, fasting blood glucose (FBG) concentrations, and lipid profiles in diabetic rats. Methods: Twenty-four Wistar rats (weight: 200–250 g) were randomly assigned into four groups as follows: (1) control (Cnt), (2) diabetic (Dibt), (3) diabetic HIIT (Dibt-HIIT), and (4) diabetic END (Dibt-END). For inducing diabetes, after 12 h of food starvation, nicotinamide (120 mg/kg) and streptozotocin (STZ; 65 mg/kg) were intraperitoneally injected. The diabetic training groups received 10 weeks of HIIT or END training following the induction of diabetes. Twenty-four hours following the last training session, blood serum samples were collected for evaluating the concentration of irisin, betatrophin, and insulin hormones through enzymelinked immunosorbent assay. Results: FBG and lipid profiles were measured by biochemical kits. A significant increase in the serum concentration of irisin (p < 0.05), betatrophin (p < 0.05), and insulin (p < 0.001) and significant decrease in the FBG (P < 0.01) and lipid profiles (p < 0.01) were observed in the Dibt-HIIT group compared to the Dibt-END group. In addition, irisin revealed a significant positive association with betatrophin and insulin values in diabetic training groups (p < 0.01). Conclusions: It seems that HIIT leads to a more extensive improvement in diabetic conditions compared to the END training. Therefore, HIIT appears to be an important time-efficient approach for the treatment of type 2 diabetes. Keywords: diabetes mellitus, exercise, endurance training, insulin, streptozotocin