2024 : 10 : 15
Mohammad Ali Bodaghifard

Mohammad Ali Bodaghifard

Academic rank: Associate Professor
ORCID: https://orcid.org/0000-0001-9732-4746
Education: PhD.
ScopusId: 6507703429
HIndex:
Faculty: Science
Address: Arak University
Phone:

Research

Title
An immobilized Schiff base–Mn complex as a hybrid magnetic nanocatalyst for green synthesis of biologically active [4,3-d]pyrido[1,2-a]pyrimidin6-ones
Type
JournalPaper
Keywords
Magnetic nanocatalyst, Green Synthesis, pyrimidinones
Year
2024
Journal Nanoscale Advances
DOI
Researchers Mohammad Ali Bodaghifard ، NAJMIEH AHADI

Abstract

The immobilization of metal ions on inorganic supports has garnered significant attention due to its wide range of applications. These immobilized metal ions serve as catalysts for chemical reactions and as probes for studying biological processes. In this study, we successfully prepared Fe3O4@SiO2@Mncomplex by immobilizing manganese onto the surface of magnetic Fe3O4@SiO2 nanoparticles through a layer-by-layer assembly technique. The structure of these hybrid nanoparticles was characterized by various analytical techniques, including Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and inductively coupled plasma-optical emission spectrometry (ICP-OES). Fe3O4@SiO2@Mn-complex was successfully utilized in the synthesis of biologically active 7-aryl[4,3-d] pyrido[1,2-a]pyrimidin-6(7H)-one derivatives in an aqueous medium, providing environmentally friendly conditions. The desired products were manufactured in high yields (81–95%) without the formation of side products. The heterogeneity of the solid nanocatalyst was assessed using a hot filtration test that confirmed minimal manganese leaching during the reaction. This procedure offers numerous advantages, including short reaction times, the use of a green solvent, the ability to reuse the catalyst without a significant decrease in catalytic activity, and easy separation of the catalyst using an external magnet. Furthermore, this approach aligns with environmental compatibility and sustainability standards.