2024 : 10 : 13
Mohammad Ali Bodaghifard

Mohammad Ali Bodaghifard

Academic rank: Associate Professor
ORCID: https://orcid.org/0000-0001-9732-4746
Education: PhD.
ScopusId: 6507703429
HIndex:
Faculty: Science
Address: Arak University
Phone:

Research

Title
Green and Convenient Synthesis of Pharmaceutically Active Mono and Bis-dihydroquinazolines via a One-pot Multicomponent Reaction Under Sulfamic Acid Catalysis
Type
JournalPaper
Keywords
Dihydroquinazolines, sulfamic acid, multicomponent reaction, pharmaceutical, eco-friendly condition, green synthesis.
Year
2024
Journal Current Green Chemistry
DOI
Researchers Amir Samiei ، Mohammad Ali Bodaghifard ، Mahdia Hamidinasab

Abstract

ract Introduction: Multicomponent reactions (MCRs) and green chemistry are essential criteria for the development of efficient chemical syntheses for valuable organic compounds. Methods: The design, synthesis, and development of sustainable procedures for the production of novel biological and pharmaceutical molecules have gained high importance. Herein, an environmentally benign synthesis of mono- and bis-2,3-dihydroquinazolin-4(1H)-ones as pharmaceutically active compounds was carried out in good to high yields of 80-99% within 45-120 minutes. Results: The desired products were synthesized via three-component and pseudo five-component condensations of isatoic anhydride, a primary amine (aniline or ammonium acetate), and an aldehyde/dialdehyde using sulfamic acid (20%) as a solid acidic catalyst under the solvent-free condition at 100°C. Conclusion: The easy work-up procedure, metal-free and environmentally benign catalyst, green reaction conditions for performing MCRs, and high yields of pure products are some advantages of the presented protocol.