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Hamid Khanmohammadi

Hamid Khanmohammadi

Academic rank: Professor
ORCID: https://orcid.org/0000-0001-5600-4738
Education: PhD.
ScopusId: 22734138900
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis, biological and computational study of new Schiff base hydrazones bearing 3-(4-pyridine)-5-mercapto-1,2,4-triazole moiety
Type
JournalPaper
Keywords
1,2,4-triazole, Schiff base, hydrazones, antibacterial, antifungal, ab initio
Year
2008
Journal Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI
Researchers Hamid Khanmohammadi ، Mohammadhossein Abnosi ، Ali Hoseinzadeh ، Maliheh Erfantalab

Abstract

A series of new Schiff base hydrazones (compounds 1-16) were synthesized by condensation reaction of 4-Amino-3-(4-pyridine)-5-mercapto-1,2,4-triazole with various aldehydes and/or dialdehydes. The structure of the prepared compounds was confirmed by means of 1H NMR, 13C NMR, UV.vis., IR and elemental analyses. The all prepared compounds were assayed for antibacterial (Escherichia coli and Staphylococcus aureus) and antifungal (Candida albicans) activities by disc diffusion method. The results indicate that all tested compounds did not show any antibacterial activity against E.coli, as gram negative bacteria, and antifungal activity against Candida albicans. But the compounds 2, 3, 4, 6 and 8 containing 4-Cl, 4-Me, 4-MeO, 2,4-di-Cl and 2-OH substituted phenyl moiety, respectively, showed good inhibition against S. aureus as compare to standard drugs. The structure of all biologically active compounds has also been theoretically studied by ab initio Hartree–Fock (HF) methods.