2024 : 6 : 17
Farhad Heidary

Farhad Heidary

Academic rank: Assistant Professor
ORCID: https://orcid.org/0000-0002-3650-6164
Education: PhD.
ScopusId: 37006703300
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis of carbon nanostructures using hydrothermal method and investigation of its application in drug release control
Type
JournalPaper
Keywords
Drug release, Polymer nanocomposite, Tetracycline, Chitosan
Year
2024
Journal Colloid and Nanoscience Journal
DOI
Researchers Farhad Heidary ، Fatemeh Sadat Farzin Pour

Abstract

The aim of this research is to achieve regular and controlled drug release. For this reason, improving and increasing the quality and ability of drug delivery systems has been of great interest. A very important issue in the drug delivery system is to achieve a stable and resistant formulation in such a way that it greatly increases the effectiveness of the drug in the target tissue by circulating and releasing the drug at a certain time. With this aim, biodegradable polymers are used due to their availability, biodegradability, easy manufacturing, and nanoparticles to control the rate of drug release into the body. In this research, the synthesis of carbon nanostructure was carried out using carrot juice extract by hydrothermal method, and the suitable temperature for synthesis was investigated. The results showed that heating for 24 hours at a temperature of 180 0C is suitable. Then, polymer nanocomposites consisting of chitosan, gelatin, carbon nanostructure and tetracycline drug were prepared. The results showed that nanostructures coated with polymer lead to better drug delivery performance. FTIR, SEM and XRD were used to characterize the prepared carbon nanostructure. The optimal samples containing 0.015 g of carbon nanostructure showed the best performance compared to other samples in drug release.