2024 : 4 : 19
Alireza Karimi

Alireza Karimi

Academic rank: Professor
ORCID: https://orcid.org/0000-0001-5006-8642
Education: PhD.
ScopusId: 57217189368
Faculty: Science
Address: Arak University


Preparation of Chitosan Hydrogels Containing Ruhemann’s Purple and Zn(II) Complex of Ninhydrin with Antibacterial and Antioxidant and Photodynamic Therapy Properties
Ninhydrin · Photosensitizing hydrogel · Photodynamic therapy · Ruhemann’s purple · Zn(II) complex of ninhydrin derivatives
Journal ChemistrySelect
Researchers fatemeh dusti ، Alireza Karimi ، Mahnaz Hadizadeh


In this study, homogeneous hydrogels based on chitosan containing ninhydrin derivatives, including Ruhemann’s purple (RP) and its Zn(II) Schiff base chelate of indane-l,3-dione-2- imine-N-acetic acid (Zn(II)IDIA), as photosensitizers have been synthesized with the potential of photodynamic therapy (PDT) applications. Ninhydrin is a valuable organic compound that exhibits bacteriostatic, virucidal, and anti-diabetogenic properties. This study describes how the use of ninhydrin is a viable option for the investigation of in vitro PDT activities. The hydrogels were prepared through chemical cross-linking using glutaraldehyde and loaded with water-soluble photosensitizers. According to the results, the hydrogels demonstrated a threedimensional (3D) porous morphology, remarkable singlet oxygen generation, antibacterial activity, and good mechanical strength. The results of the cell viability assay illustrated their excellent biocompatibility and safety. All the information in this study supports the capability of the hydrogels containing RP and Zn(II)IDIA for PDT treatment.