2024 : 4 : 21
Alireza Karimi

Alireza Karimi

Academic rank: Professor
ORCID: https://orcid.org/0000-0001-5006-8642
Education: PhD.
ScopusId: 57217189368
Faculty: Science
Address: Arak University
Phone:

Research

Title
Preparation and Evaluation of a Sulfadimethoxine-Conjugated Hydrogel Based on N-isopropylacrylamide as a Sustained Release Drug Delivery System
Type
JournalPaper
Keywords
Drug-conjugated hydrogelDrug deliveryNanoparticlesPNIPAAmSustained release
Year
2022
Journal Chemistryselect
DOI
Researchers Hesam Khorsandi ، Alireza Karimi ، Farnaz Azadikhah

Abstract

The burst release of drugs limited the development of the thermo-responsive hydrogels based on poly N-isopropylacrylamide (NIPAAm) for application in drug delivery systems. To overcome this problem, the drug sulfadimethoxine (SDMO) was conjugated via amide bond to the PNIPAAm hydrogel instead of loaded into the system. Therefore, SDMO was modified using maleic anhydride to get N-maleyl sulfadimethoxine (NMSDMO) and then utilized that to synthesize the sulfadimethoxine-conjugated PNIPAAm hydrogel (P[NIPAAm-co-NMSDMO]). The resultant monomer was then grafted into the hydrogel network at different weight percentage through radical polymerization. The NMSDMO monomer and the P[NIPAAm-co-NMSDMO] hydrogels were fully investigated. The in vitro drug released displayed sustained release in pH 5 and 7.4 for 24 h. Hydrolysis of the amide bond causes the release rate and total amount of drug to be greatest at pH 5, as compared to pH 7.4. As a result, the P[NIPAAm-co-NMSDMO] hydrogel was an effective sustained drug delivery system.