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Akbar Mobinikhaledi

Akbar Mobinikhaledi

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-9732-7282
Education: PhD.
ScopusId: 6701730547
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis of Some Novel Chromenopyrimidine Derivatives and Evaluation of Their Biological Activities
Type
JournalPaper
Keywords
Imine; Chromenopyrimidine; Pyranopyrimidine; Antibacterial; Multicomponent.
Year
2014
Journal Iranian Journal of Pharmaceutical Research
DOI
Researchers Akbar Mobinikhaledi ، Naser Forougifar ، Tahere Mosleh ، Ahmad Hamta

Abstract

Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR (1 H and 13 C) spectroscopy and elemental analysis data. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922).