سامانه پژوهشی دانشگاه اراک | Sulfonic acid Grafted onto TiO2-Coated Nickel ferrite Nanoparticle as an Efficient, Magnetically Separable and Reusable Heterogeneous Solid acid catalyst for Green and One-pot Synthesis of 2H-Indazolo[2,1-b]phthalazine trione Derivatives.

عنوان	Sulfonic acid Grafted onto TiO2-Coated Nickel ferrite Nanoparticle as an Efficient, Magnetically Separable and Reusable Heterogeneous Solid acid catalyst for Green and One-pot Synthesis of 2H-Indazolo[2,1-b]phthalazine trione Derivatives.
نوع پژوهش	مقاله ارائه‌شده
کلیدواژه‌ها	2H-Indazolo[2,1-b]phthalazine trione , Green chemistry
چکیده	Phthalazine derivatives possess properties such as antimicrobial[1], anticancer[2] and etc. activities. One pot synthesis of 2H-Indazolo [2, 1-b] phthalazine-trione derivatives with various homogenous and heterogeneous catalysts reported in literatures [3-6] Nanocatalysis is now an important area in the field of nano science and catalysis. In recent years, use of magnetic nano particles(MNPs) due to supermagnetic behavior and easy separation from the reactions media, large surface area, low toxicity, good stability and possible functionalization and etc. is gained more interest in chemical reactions [7].For developing the green procedures for the synthesis of valuable heterocycles, herein, we wish to report an environmentally benign protocol for the synthesis of pharmaceutically important phthalazine-trion derivatives via three-component condensation of phthalhydrazide, dimedone and aldehydes in the presence of sulfonic acid grafted nickel ferrite nano particles in solvent free condition (scheme 1).
پژوهشگران	اکبر مبینی خالدی (نفر دوم)، مهدیا حمیدی نسب (نفر اول)

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