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چکیده
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Recently, hybrid material using poly ethylene glycol and porous nanocrystals have been developed for drug release. In this study, a series of poly ethylene glycol (PEG)/NaY zeolite and PEG/MCM-41 nanocomposites synthesized. These materials characterized by using FT-IR spectroscopy, XRD, TGA and SEM. After it ibuprofen loaded onto these nanocomposites. Ibuprofen was encapsulated into synthetic nanocomposites, then the release profile of these drug loaded nanocomposites was evaluated in different pH (1-12) and different temperatures (36-40°C) at certain time intervals by using a HPLC method. The results show the same profile similar to ibuprofen-only dissolution profile except to the drug release percent which is lower than ibuprofen-only profile. The effect of temperature on the release amount of loaded-ibuprofen shows an interesting result; the increasing the temperature, the decreasing the release amount of ibuprofen. Result show that these nanocomposites have further release related to NaY , MCM-41 and the orders of release in different pH were PEG/NaY> PEG/MCM-41> NaY> MCM-41.The behaviour of drug release for these nanocomposites is probably due hydrogen bonding interaction between drug and the hydroxyl group on the composite framework.
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