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Seyed Mohammadali Shariatzadeh

Seyed Mohammadali Shariatzadeh

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-2395-8057
Education: PhD.
ScopusId: 15133044400
HIndex:
Faculty: Science
Address: Arak University
Phone:

Research

Title
Investigating The Effect Of Empagliflozin on The Number Of The Spermatogenic, Sertoli And Leydig Cells in The Diabetic Rats
Type
Presentation
Keywords
Empagliflozin, Leydig Cells, Spermatogenic Cells, Sertoli Cells, Type 2 Diabetes,
Year
2023
Researchers Mina Kiani ، Malek Soleimani mehranjani ، Seyed Mohammadali Shariatzadeh

Abstract

Background: Empagliflozin has antioxidant properties. An in- crease in blood sugar causes increase in the level of oxidative stress and a disturbance in the glucose metabolism of the testis. We aimed to investigate the effect of empagliflozin on the num- ber of spermatogenic, Sertoli and Leydig cells in diabetic rats. Materials and Methods: 18 adult male rats were divided into control, diabetic (streptozotocin (65 mg/kg b.w) and nicotinamide (110mg/kg b.w), intraperitoneal injection) and diabetic+Empagliflozin group (10 mg/kg b.w/day, gavage, 8 weeks). After 8 weeks, IUR sections were prepared from the right testis and after tissue passage, 20 μm thick sections were prepared. spermatogenic, Sertoli and Leydig cells were count- ed. The data were analyzed using ONE-WAY ANOVA and Tuk- ey's test, and the significance level was P<0.05. Results: A significant decrease in the number of spermatogo- nia cells, primary spermatocytes, round spermatids, elongated spermatids, Sertoli, and Leydig cells were observed in the dia- betic group compared to the control (P<0.001). In the diabetic+ Empagliflozin group the average number of spermatogonia cells and primary spermatocytes (P<0.01), round spermatids (P<0.001), elongated spermatids (P<0.001), Sertoli (P<0.01) increased significantly compared to the diabetic group(P˃0.05). Conclusion: Empagliflozin improves the effects of type 2 dia- betes on the number of spermatogenic and Sertoli cells but does not affect the number of Leydig cells.