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Monireh Mahmoodi

Monireh Mahmoodi

Academic rank: Assistant Professor
ORCID: https://orcid.org/0000-0001-8383-6150
Education: PhD.
ScopusId: 35102803500
HIndex:
Faculty: Science
Address: Arak University
Phone:

Research

Title
N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress
Type
JournalPaper
Keywords
بدون کلیدواژه
Year
2015
Journal Reproductive BioMedicine Online
DOI
Researchers Monireh Mahmoodi ، Malek Soleimani mehranjani ، Seyed Mohammadali Shariatzadeh ، hussein Eimani ، Abdulhussein shahverdi

Abstract

The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4–5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before until 7 days after transplantation. After 28 days, ovary compartments were estimated stereologically. Plasma malondialdehyde, progesterone, oestradiol concentrations and the percentage of apoptotic follicles were measured to evaluate the rate of oxidative stress and ovarian graft function. The mean total volume of ovary, cortex and the number of follicles was significantly higher (all P < 0.001) in the autografts plus NAC group compared with the saline group. In the autografts plus NAC group, the mean percentage of apoptotic follicles (P < 0.001) and malondialdehyde concentration (P < 0.001 day 7; P < 0.05 day 28) were significantly lower, whereas oestradiol concentration was significantly higher (P < 0.05) compared with the saline group. Although NAC cannot compensate the above parameters to the control level, it considerably improves follicular survival and development and also the structure and function of transplanted ovaries, through reducing oxidative stress and apoptosis.