The importance of physical activity in enhancing overall health at any age is well documented. Some conditions, such as avoiding going to the gym or facing urgent circumstances (e.g. the coronavirus pandemic), can lead to a more sedentary lifestyle and increase the risk of chronic diseases. Home-based training is an effective way to stay active at home. This review aims to offer various methods for alternative and practical home-based activity programs to enhance fitness levels. This is especially important when preventive measures, such as quarantine, are necessary to ensure isolation and minimize interpersonal contact. During quarantine, it's iessentialfor adults, especially those with chronic diseases, to exercise regularly.T he method was library-based; new books and articles on physical activity at home were reviewed, and the scientific basis for performing physical activity at home was provided. Various physical activities using the devices at home and exercises without using the devices were examined. Practical suggestions for staying active at home, along with aerobic exercise, including walking, running on a treadmill, proper use of stationary bikes, and body weight resistance exercises, were provided. In Conclusion, this guidance provides valuable information on home-based physical activities for sedentary individuals to improve their health.