Abstract Background and purpose: the aim of this study was to investigate effect of resistance training (RT) on oxidative stress and total antioxidant capacity in rats treated with cisplatin. Materials and methods: In this experimental study, 21 Sprague dawley rat model were randomly divided into 3 groups: control (n=7), control cisplatin (n=7) and cisplatin with RT (n=7). In cisplatin groups, 10mg/kg cisplatin was injected intraperitoneally. The training groups also performed the training for 10 weeks. 24 hours after last training session, blood serum of rats was collected to examine desired variables. Data were analyzed using one-way analysis of variance at the significant level of P≤0.05. Results: In this study, cisplatin injection caused a significant increase in malondialdehyde (MDA) (P=0.001), a significant decrease in total antioxidant capacity (TAC) (P=0.001), and a significant decrease in catalase (CAT) in the control group. Compared to cisplatin control. Malondialdehyde (MDA) was also significantly reduced in the cisplatin group with RT (P=0.001) compared to the cisplatin control group. In addition, no significant difference was observed in total antioxidant (TAC) in the cisplatin group with RT (P=0.227) compared to a healthy control group. Also, catalase (CAT) in cisplatin group with RT (P=0.404) was not significantly different from the control group. Conclusion: It seems that exercise with different intensities can be effective in reducing the oxidative stress conditions caused by cisplatin in rats.
