Abstract Background & Aim: Lipasin is a liver-derived secretory protein; i.e. associated with type 2 diabetes mellitus, obesity and metabolic syndrome. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) intensities on serum levels of lipasin and lipid profile in obese male rats. Materials and Methods: In this experimental study, 20 obese rats (8 weeks old, Mean±SD weight: 361±32 g) and 10 normal-weight rats (8 weeks old, Mean±SD weight: 236±15 g) randomly divided into three groups: obese control, obese trained, and control. The obese trained group received an 8-week exercise program for 5 days/week, the high-intensive interval training (HIIT) protocol was conducted on the treadmill 5 channel due to easier control speed and time. Forty-eight hours after the last training session, the blood samples were obtained and analyzed for metabolic status. The collected data were analyzed using analysis of variance (ANOVA), and statistical significance was set at P<0.05. Results: Lipasin levels were higher in obese rats, than the controls (P=0.01). Atherogenic and metabolic status (TG, TC, LDL, glucose, insulin resistance) were improved in the exercise group, compared to the control group (P=0.05). Plasma lipasin levels were significantly decreased in the obese exercise group (P=0.05). Conclusion: This study indicated that high-intensity interval training (HIIT) may be effective in improving metabolic status by decreasing lipasin plasma levels.
