Foot and mouth disease (FMD) is a highly contagious viral disease of ruminant which causes fever and postule on mouth, hoof and teat [1, 2]. The disease is causing heavy economic losses to the dairy industry. The purpose of this paper is to study of the control of FMD infection in dairy calf on Markazi province (Farahan section) with smoke of Peganum harmala L seeds and Donkey excrement. In this study dairy calves divided to 3 group: Normal (healthy) calves (control), Calves in the early stages of the disease (G1) and Calves with advanced disease (G2). In G3 we used smoke of Peganum harmala L seeds and Donkey excrement and Gentamicin and Flunixin Meglumin. In G2 and control used only smoke of Peganum harmala L seeds and Donkey excrement . Results showed that in tree group calves were improved.
