Background: Platinum-based chemotherapy, a cornerstone in cancer treatment, can induce hepatotoxicity. Exercise can mitigate adverse effects of chemotherapy, including liver damage. This study aimed to investigate the protective effects of moderate-intensity continuous training (MICT) on liver function and lipid metabolism in rats induced with Platinol. Materials and Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups: A healthy control group, a platinol-injected control group, a MICT group, and a platinolinjected group with MICT. Serum liver enzymes alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST) and lipid profiles were measured after 10 weeks of training or platinol injection. Results: MICT significantly reduced serum levels of AST, ALT and ALP in platinol-induced rats, comparable to healthy controls. Additionally, MICT improved lipid profiles by reducing cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol (HDL). Conclusion: MICT may be a promising intervention to mitigate platinum-induced liver toxicity and dyslipidemia. Further research is warranted to explore the potential clinical implications of these findings for cancer patients undergoing chemotherapy.
