Background: Cisplatin, while effective in cancer treatment, often induces adverse effects, including inflammation and dyslipidemia. This study investigated the impact of moderateintensity continuous training (MICT) and high-intensity interval training (HIIT) on these cisplatininduced alterations in rats. Methods: Thirty-two Sprague-Dawley rats were randomly allocated to a healthy control group, a cisplatin control group, a cisplatin group with MICT, and a cisplatin group with HIIT. Cisplatin (5 mg/kg) was administered intraperitoneally, followed by a 10-week exercise training regimen. MICT involved five weekly sessions over ten weeks, starting at 10 m/min for 15–20 minutes and increasing to 27 m/min for 60 minutes by week three. HIIT included five weekly sessions with 3–20 intervals of two minutes at 54 m/min and one-minute active recovery at 16 m/minute. The serum levels of inflammatory markers (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]) and lipid profile (total cholesterol [TC], triglycerides [TG], low-density lipoprotein cholesterol [LDL], and high-density lipoprotein cholesterol [HDL]) were quantified. Results: Cisplatin significantly elevated IL-6, tumor necrosis factor-alpha (TNF-α), TC, TG, and LDL-C while reducing HDL-C compared to HC (P<0.05). Both MICT and HIIT significantly attenuated cisplatin-induced increases in IL-6, TNF-α, TC, TG, and LDL-C (P<0.05) and reversed the decrease in HDL-C (P<0.05). There were no statistically significant differences between the MICT and HIIT groups in terms of inflammatory markers or lipid profiles (P>0.05). Conclusion: Both MICT and HIIT effectively mitigated cisplatin-induced inflammation and dyslipidemia in rats. These findings suggest that exercise training may be a promising adjunct therapy for ameliorating the side effects of cisplatin-based chemotherapy.
