The rapid evolution of smart nano-bio-physio sensing platforms has revolutionized point-of-care (POC) tech nologies, offering unprecedented opportunities for real-time health monitoring, disease diagnosis, and person alized medicine. This review comprehensively explores the integration of advanced nanomaterials (e.g., carbon nanotubes, quantum dots, MXenes) with bio-physio sensors to enhance sensitivity, selectivity, and signal transduction in electrochemical, optical, and mechanical systems. We highlight key advancements in self- powered triboelectric/piezoelectric nanogenerators, wearable epidermal devices, and paper-based colorimetric sensors, emphasizing their applications in glucose monitoring, vital sign tracking, and infectious disease detection. Furthermore, we discuss the engineering challenges of system miniaturization, IoT connectivity, and biocompatibility, along with regulatory hurdles for clinical adoption. By critically analyzing current limitations and prospects, this work provides a roadmap for next-generation smart sensor ecosystems that bridge nano technology, biotechnology, and artificial intelligence to transform decentralized healthcare.
