Objective: Platinol is a widely used chemotherapy agent that offers therapeutic benefits for cancer treatment, but its adverse effects limit its use. On the other hand, physical activity has been suggested as a potential strategy to deal with these side effects, hence the aim of this study is to investigate a period of endurance training on the serum level of interleukin-6, tumor necrosis factor alpha and lipid indices in rats. It was induced by Platinol. Materials and Methods: In this study, 25 men with type 2 diabetes (mean age 59.88 ± 9.64 years, height 172.36 ± 8.92 cm, weight 75.59 ± 9.75 kg, body fat percentage 19.18 ± 4.43, and body mass index 25.61 ± 3.72 kg/m²) were divided into three groups: control (n=8), exercise and supplement (n=8), and placebo (n=8). After 8 weeks of resistance training and daily consumption of two 200 microgram tablets of chromium picolinate (by the exercise and supplement group), blood samples were taken to measure the hormones of the HPG axis. Results: The results showed that Platinol significantly increased the serum levels of interleukin 6 and tumor necrosis factor alpha in the Platinol control group (p≤0.05). Also, 8 weeks of endurance training caused a significant decrease in serum levels of interleukin-6 and tumor necrosis factor alpha in the Platinol group and endurance training compared to the Platinol control group (p≤0.05). Total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) in Platinol control were significantly higher than other groups (p≤0.05). But high-density lipoprotein (HDL-C) was lower in the Platinol control group. On the other hand, 8 weeks of endurance training resulted in a significant decrease in LDL, TC and TG (p≤0.05). Conclusion: Based on the findings of the present study, it seems that sports activity can reduce inflammatory responses and improve blood lipid indices in rats induced with platinol.
