In this study, the central composite design was used for modeling and optimizing the new study of the removal of phthalocyanine dye using magnetic nanoparticles iron oxide modified by ployaspartic acid (Fe3O4-PAs). Based on the results of CCD, the optimized conditions for initial concentration of phthalocyanine dye (C), and adsorbent dosage (m), pH variables are 40 mg/L, 9 mg, and 3.3 respectively that lead to %R = 99. In addition to these studies, the investigations of the dye desorption and the adsorbent reusability are complementary divisions of this research.