عباس صارمی

Background: Alzheimer's is one of the diseases related to old age, which is associated with dementia and cognitive problems in patients. Utilizing safe and low-cost treatment approaches, such as exercise and natural antioxidants, can be a beneficial way to manage this disease. Objectives: Therefore, the purpose of this study is to investigate the effect of resistance exercise and receiving sumac on the level of interleukin1- beta and nitric oxide in Alzheimer's rats. Methods: In an experimental study, 28 Wistar rats (aged 8 - 10 weeks and with an average weight of 230 ± 30 grams) were selected and randomly divided into four groups of seven: Alzheimer's control, Alzheimer's induced by resistance exercise, Alzheimer's resistant + consumption of sumac, and Alzheimer's induced by sumac. 10% of sumac powder was used in rats' food (10 mL/kg). To induce Alzheimer's in mice, an amount of 8 mg/kg of body weight of trimethyltin chloride was used, along with 200 microliters of Thermal saline as a solvent was injected intraperitoneally into the mice. Resistance training was carried out for 12 weeks, 5 days a week, in the form of climbing with weights attached to the mice's tails from a one-meter-long ladder with 26 steps and an angle of 85 degrees. 48 hours after the last intervention session, serum levels of nitric oxide and interleukin1- beta (IL1B) were measured by the ELISA method.