Abstract Multiple diseases can decrease levels and changes in gut microbial populations, while increasing microbiota diversity causes an increase in the immune response. Evidence shows that exercise can afect the gut microbiota and, subsequently, the health of individuals. Also, regular exercise provides many benefts for health, protection against the spread of chronic diseases, and improved quality of life. Exercise can increase the number of helpful microbiota species, enrich microfora diversity, and improve the growth of commensal microbiota. This article reviews recent fndings on the interaction of gut microbiota and exercise. Also, another purpose of this research is to suggest diferent mechanisms that using them can provide the way that the exercise factor can change the gut microbiota.