Entrepreneurship, in interaction with market orientation, plays a decisive role in improving and enhancing business performance. The purpose of this study is to evaluate the impact of entrepreneurship on the performance of carpet production business considering the mediating role of market orientation in the relationship between these two variables. In this applied research, with the help of questionnaire tools, 38 design questions and initial data were collected and analyzed by descriptive-causal method. The statistical population of the study includes the manufacturers of handmade carpet business in Fars province. So, using stratified random sampling and Cochran's formula, 100 people were selected as the sample size. Data analysis was performed using structural equation method. The test results of the research hypotheses confirm the effect of market orientation on the business performance of handmade carpet production and there is a significant relationship between entrepreneurship and performance directly and also due to market orientation between factors.