Background: Although ovarian tissue transplantation is used to preserve fertility in young women undergoing chemotherapy, but due to the occurrence of ischemia- reperfusion injury and oxidative stress, ovarian function is disturbed and large amounts of follicles are lost. Alpha-lipoic acid (ALA) is a strong free radical scavenger used in the prevention of oxidative stress and cellular damage. Objective: We aimed to investigate the effect of ALA on the serum level of malondialdehyde (MDA) and total antioxidant capacity (TAC) following mouse ovarian tissue transplantation. Materials and Methods: 24 mice were randomly divided into: control, autograft (ovarian tissue tr nspl nt to t glut us sup rfi l s mus l ) n autograft + ALA (100 mg/kg intraperitoneal injections of ALA 30minutes prior to transplantation). Serum concentrations of MDA and TAC were measured 7 days after ovary transplantation. Data were analyzed using one-w y ANOVA n Tu k y‟s t st n t m ns were considered significantly different at p-value < 0.05. Results: The MDA level in the autograft group significantly increased in compare to the control, while it showed a significant decrease in the autograft + ALA group compared to the autograft group (p < 0.05). Moreover, the serum level of TAC decreased significantly in the autograft group compared to the control counterpart, whereas it increased significantly in the autograft + ALA group compared to the autograft group (p < 0.05). Conclusion: ALA can reduce oxidative stress and cell damages following ovarian tissue transplantation which can improve the function of the grafted ovary.
