Background: Although ovarian tissue transplantation is one of the options for maintaining fertility in cancer patients, however, this method also faces limitations such as ischemic-reperfusion that is able to cause disorder in the endocrine function of the transplanted ovary. Alpha-lipoic acid (ALA) act as strong an- tioxidants through free radical quenching and recycling of oth- er cellular antioxidants. We aimed to investigate the effect of α-lipoic acid on the serum level of progesterone and estradiol following mouse ovarian tissue transplantation. Materials and Methods: 18 Mice were divided into: control, autograft + saline (whole ovarian tissue transplanted in the glu- teus superficialis muscle, receiving intraperitoneal injections of saline), autograft + ALA (receiving 100 mg/kg" intraperitoneal injections of ALA, 30 minutes before transplantation). 28 days after ovary transplantation, serum concentrations of progester- one and estradiol were assayed. Statistical analysis was done with one-way ANOVA and Tuckey’s test and the means were considered significantly different at p value < 0.05. Results: Serum concentrations of progesterone and estradiol in the autograft group decreased significantly compared to the control, while it showed a significant increase in the autograft + ALA group compared to the autograft group (p < 0.05). Conclusion: Lipoic acid can improve the hormonal and endo- crine function of the transplanted ovarian tissue by reducing ischemic reperfusion injury.
