Water resource management has emerged as a pivotal concern within arid regions in recent times. The water footprint (WFP) index stands out as a principal gauge for facilitating comprehensive watershed management. This study endeavors to compute the WFP of diverse agricultural products encompassing major crops, orchards, cucurbits, and medicinal plants across arid regions. This research focuses on three distinct climate scenarios: the Shazand Plain with a semidry climate, the Khomein Plain characterized by a dry climate, and the Saveh Plain exhibiting a very dry climate. This study also seeks to ascertain the climate most conducive to cultivating crops from a WFP (green, blue, and gray) perspective. To achieve these objectives, this study employed the CropWat family software to determine crop water requirements, as well as considering crop yield and relevant parameters for calculations. The findings of the investigation unveiled that the cultivated areas in the respective climates amounted to 19,479 ha (semidry), 18,166 ha (dry), and 41,682 ha (very dry). These areas were allocated as follows: 88%, 85%, and 55% for crops; 11%, 13%, and 40% for orchards; and 1%, 2%, and 5% for cucurbit crops. Importantly, the very dry climate was predisposed to allocating more land for low-water-demand orchards. Among the major crops, wheat occupied 44%, 39%, and 43% of the total areas in the semidry, dry, and very dry climates, respectively. Analyzing the overall agricultural output in these climates, it was revealed that over 79%, 69%, and 66% of production correlated with crops; 17%, 19%, and 22% with orchards; and 4%, 12%, and 12% with cucurbits, respectively. In terms of water consumption, maize and apples emerged as the highest performers, with varying consumption patterns across different crops. Interestingly, canola exhibited a substantially higher WFP, surpassing wheat and barley by 56.48% and 58.85%, respectively, in dry climates. Cucurbit crops, on the other hand, displayed a lower WFP in dry climates, which could potentially encourage their cultivation. The influence of climate warming on canola’s WFPgray introduced complexity, challenging the conventional correlation between WFP and yields. Medicinal plants consistently demonstrated lower WFP values, underscoring the need for deliberate and considerate cultivation decisions in this regard.