The immense volume of highly polluted organic wastewater continuously generated in the beverage industry urges the design of new types of wastewater treatment plants. This study aimed to evaluate the applicability of the electro-Fenton (EF) technique to reduce organic pollution of real effluent from a carbonated soft drink factory. The impact of various process variables like pH, time, current density, H2O2/Fe2+ molar ratio, and the volume ratio of H2O2/soft drink wastewater (SDW) was analyzed using response surface methodology (RSM). The observed responses were in good agreement with predicted values obtained through optimization. The optimum conditions showed a chemical oxygen demand (COD) removal efficiency of 73.07 %, pH of 4.14, time of 41.55 min, current density of 46.12 mA/cm2 , H2O2/Fe2+ molar ratio of 0.9802, and H2O2/SDW volume fraction of 2.74 ml/l. The EF process was able to effectively diminish the organic pollution, reduce the residence time and, therefore, the operating costs.