Objectives: Chronic diseases impact the physical health of individuals and have a far-reaching impact on their quality of life, productivity, and overall well-being. Chronic diseases place a substantial financial strain on healthcare systems due to their prolonged treatment, specialized attention, frequent hospitalizations, and costly interventions. Given the significant impact of chronic diseases, it is crucial to understand their characteristics, origins and outcomes. The aim of this thesis is to enhance the existing knowledge on the epidemiology of chronic diseases by examining their prevalence, incidence, and risk factors. Design and Methods: a cross-sectional design to investigate the link between diabetes mellitus and other chronic conditions such as hypertension and renal failure. The study will not include participants who disclose having a chronic illness or taking medication for one. 120 Participants will be divided into 15 patients in control group and the rest will be divided into 7 groups for combined diseases. Results: The comparative study examining the relationship between several parameters in patients with hypertension, kidney failure, and diabetes mellitus yielded insightful findings. Notably, the data revealed distinct patterns of correlation among these conditions. In patients with hypertension, there was a statistically significant association between blood pressure levels and the severity of kidney dysfunction, emphasizing the interplay between these two factors. Furthermore, the analysis demonstrated a complex relationship between diabetes mellitus and kidney failure, with glycemic control appearing to influence renal function. Conclusions:Our study explored the association between various biomarkers in patients with diabetes mellitus, either as a sole condition or in combination with hypertension and kidney failure.