Wetlands as one of the most fragile ecosystems worldwide have been seriously affected by different natural and anthropogenic factors such as global climate change, land use change, and excess resource consumption. To investigate such adverse effects, we studied Parishan International Wetland situation over 25 years from 1991 to 2015. In order to detect the change trend and processes of the wetland, Landsat Satellite images were used over the time duration mentioned above. Supervision and maximum likelihood methods were used in the process of image classification. We used logistic regression analysis to investigate the relation between the volume of water in the wetland and the parameters of temperature, evaporation, precipitation, underground water levels, and water withdrawals from wells surrounding the wetland. We found that agricultural lands and residential areas were increased around the wetland compared to 25 years ago at a rate of %10.43 and %47.8, respectively. Our analysis revealed that the wetland water volume significantly correlated with the level of underground water and water uptake from the wells surrounding the wetland.