In this work MCM41, MCM41/NaY and Clinoptilolite/MCM41/NaY composites that have CTMABr (NcethylN,N, and Ntrimethyl Ammonium Bromide) were prepared and characterized with XRD, SEM and FTIR. Also, incorporation of two model drugs (sulfamethoxazole and metronidazole) with these composite were considered. The drug adsorption assays showed that three composites adsorb consid erable amount of drugs, in particular sulfamethoxazole which was evaluated by UV spectroscopy. The results show that we have more adsorption of sulfamethoxazole for MCM41/NaY that there is a direct relationship exists between the amounts of surfactant per gram of composite. TGA shows that the composites are more stable thermally when the ad micelles contain sulfamethoxazole in their interior. The results of adsorption of sulfamethoxazole showed that approximately 70% of drug was released from MCM41/NaYsulfamethox azole system after about 24 h.
