Introduction: Flavonoids have antibacterial properties, so their antibacterial or synergistic properties can be used. Aim of this study was to investigate the antibacterial and synergistic effect of Morin flavonoid with the antibiotics Iimipenem and Ciprofloxacin on Pseudomonas aeruginosa. Materials and methods: Antibacterial properties of Morin alone and its synergistic effect with Ciprofloxacin and Imipenem antibiotics on P. aeruginosa and 9 clinically isolated samples from the wound site burn patients using disk diffusion method on Müller-Hinton agar medium and determination of minimum Inhibitory concentration (MIC) was assessed. The obtained data from this study were analyzed by SPSS software using Pearson (1-Tailed) correlation coefficient. Results:Results showed that due to the lack of bacterial growth halo in the antibiotic test of 0-5000 mg/ml Morin concentrations, this flavonoid has no antibacterial effect. While in combination with antibiotics, a synergistic effect was observed, so that the greatest effect was observed at a 5000 mg/ml Morin concentration in combination with the Ciprofloxacin antibiotic and at a 1250 µg/ml concentration in combination with the Imipenem antibiotic. Conclusion:These results indicate that Morin alone does not have an antibacterial effect but its combination with the antibiotics Ciprofloxacin and Imipenem increases their effectiveness.
