Background: The Yale Food Addiction Scale version 2.0 (YFAS 2.0) is used for the assessment of food addiction. This research intended to evaluate the validity of the Persian translation of the questionnaire and to investigate the psychological properties and the association between food addiction and anthropometric indices. Methods: In a sample of 473 nonclinical participants, food addiction, binge eating, and objectively measured anthropometric indices were assessed. Internal consistency (IC), convergent, and validity of the PYFAS 2.0 were examined. The factor structure (confirmatory factor analysis (CFA) following the 11 diagnostic indicators in addition to the plus significant distress), and the construct of the scale were evaluated. Findings: The frequencies of mild, moderate, and severe food addiction based on PYFAS 2.0 were 0.2%, 10%, and 5.5%, respectively. The findings supported a 1-factor structure. The CFA revealed a good construct validity (RMSEA = 0.043, χ2=76.38, df =41, χ2 (CMIN)/df=1.862, GFI=0.975, AGFI=0.957, IFI=0.986, RFI=0.958, ECVI=0.319, TLI=0.978). For both the diagnostic and symptom count versions, the PYFAS 2.0 presented acceptable IC (Kuder-Richardson 20 = 0.99 and McDonald omega = 0.91). Conclusion: The PYFAS 2.0 was a psychometrically sound instrument in an Iranian non-clinical population. This questionnaire can be used to study food addiction in Persian non-clinical populations. Future researches should study the psychometric characteristics of this scale in high-risk groups.