The aim of this study is to predict the trends in drug use and sensation seeking on the basis of religious orientation in students of Islamic Azad University Branch of Roodehen in the first semester of the school year 92–93. For this purpose, 120 male and female students who have been selected for a random sample of correlation between the two variables is an indicator variable and, religious orientation Alport, Zuckerman Sensation Seeking and attitude to drug use that all tests have been completed standardisation Iranian issue. As a result of this study, among variables, it can be stated that sensation seeking, experience seeking, adventure and boredom are significant predictors for basic variable (towards drug abuse), whereas diversity, avoid forbidding, internal and external religious orientation are not significant predictors for basic variable (towards drug abuse)