Objectives: Type 1 diabetes mellitus, an autoimmune condition, can coexist with other autoimmune diseases. This study sought to identify autoimmune thyroid illness that were subclinically related. With particular consideration for the patient's clinical condition and the management of their diabetes, the existence of autoantibodies was assessed. Design and Methods: Sixty type 1 diabetic patient (30 men, 30 women, mean age 10.33 years, were included in this study. Results: Diabetes patients had considerably greater serum levels of IL-10,IL6 , and TNF- than healthy controls. Stepwise regression analysis revealed that there were strongly inversed correlations between IL-6 and Anti-TPO, Anti-TG, and Anti-GAD65 antibody as well as significant positive correlations between IL-10, IL-6, and TNF-α with these antibodies. However, among diabetic patients, there were appreciably favourable associations between TSH, HbA1C, and C-peptide. Conclusions: Our study found that T1DM patients aged 1–25 had the highest incidence of thyroid antibodies (Anti-TPO and Anti-TG). IL-6, IL-10, TNF-α levels were substantially different between the control group and diabetic patients in this study (P<0.0001). Thyroid antibodies, both their presence and severity, were positively correlated with HbA1C, body mass index, serum TSH, free T4, C-peptide and serum cytokines IL-10, and TNF-α, except for IL-6. This study supports testing thyroid antibodies and function in type 1 diabetics.
