Objectives: Type 1 diabetes mellitus (T1DM), an autoimmune condition, can coexist with other autoimmune diseases. The prevalence of celiac disease (1) in people with T1DM varies around the world from 1.3 to 12% and may include a significant number of asymptomatic and unusual cases. This study sought to identify Celiac disease and autoimmune thyroid illness that were subclinically related with particular consideration for the patient's clinical condition and the management of their diabetes. Design and Methods: Sixty patients with type 1 diabetes (30 men, 30 women, mean age 10.33 years) were included in this study. The levels of serum anti-tTG and anti-Gliadin antibodies, TNF-α, IL-2, and IL-10 were analysed among patients and controls. Results: Diabetes patients had considerably greater serum levels of, IL-2, and TNF-α than healthy controls. Stepwise regression analysis revealed that there were strong positive correlations between Anti-tTG, and Anti-GAD antibodies as well as significant positive correlations between IL-2, and TNF-α cytokines. Anti-tTG was shown to have a statistically significant positive connection with serum inflammatory cytokines TNF-α and IL-2 (R = 1, P < 0.01). Conclusions: According to the results of our investigationTNFa and IL2 have important role in T1DM , CD antibody prevalence rates among T1DM patients increased with age and duration of diabetes. According to this study, type 1 diabetics should have their CD and antibodies tested.
