Sacrificial wall systems consisting of lightweight concrete blocks have several advantages including versatility and high installation speed, making them effective tools for reducing the destructive effects of blast waves. Particularly, in confined structures, they can be placed along the path of potential explosion waves such that internal failure mechanisms in the concrete blocks cause the explosion wave energy to be dissipated. Numerous factors can affect the performance of such wall systems, including the material properties, location, and physical dimensions of the concrete blocks. This research presents an in-depth computational study on parameters influencing the performance of such sacrificial wall systems.