Carbon monoxide is a tasteless and odorless gas produced by gas burning engines and the incomplete combustion of hydrocarbons. Carbon monoxide poisoning occurs due to the respiration of this gas. Lack of proper exhaust and ventilation of it causes poisoning and death. So inhalation of it reduces blood oxygenation and is dangerous. Therefore, timely and correct identification of this gas is important. Carbon monoxide is difficult to detect and can cause other common disorders. Graphene and its derivatives have been widely used for fabrication of gas sensors because they have two-dimensional atomic bonds that can interact by gas molecules. In this study, graphene oxide was used to detect carbon monoxide. In order to improve the response time, the sensitivity of the sensor and its selectivity were composite by silver and manganese nanoparticles. Graphene oxide was prepared by advanced Hummers method. Ultrasonic device was also used to prepare graphene oxide/silver and graphene oxide/manganese nanocomposite. The results show that the sensor prepared by graphene oxide/silver and graphene oxide/manganese nanocomposites are able to detect carbon monoxide at room temperature, with appropriate sensitivity and selectivity.