Sono-chemical is a fast procedure for fabricating mono-disperse nanoparticles. Magnetic nanoparticles and nano-additives have gained much attention in composite industries due to the fact that adding of a small amount of nanostructure to a composite can lead to a great improvement in physical and chemical properties of the composite. In this work we have used the sono-chemical process to successfully synthesize Fe3O4 nanoparticles. Then, cellulose acetate /Fe3O4 nanocomposite membrane was prepared to obtain a new mixed matrix membrane. Nanostructures were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM). The results showed that presence of Fe3O4 nanoparticles in the membrane structure enhanced the ions rejection.